Aquastar® CombiTitrant 5 Karl Fischer Reagent
Aquastar® CombiTitrant 5 (Supelco / Merck) is a globally recognized one-component reagent designed for volumetric Karl Fischer titration. Formulated for the direct quantification of moisture in solid, liquid, and gaseous samples, it contains all active chemical components—iodine, sulfur dioxide, and an innovative non-toxic organic base—dissolved together in an alcohol-based medium. With a nominal water equivalency of approximately 5 mg of water per milliliter of reagent (titer ~ 5 mg H2O/mL), it delivers rapid reaction kinetics and razor-sharp electrochemical endpoints for analytical laboratories across Bangladesh.
Controlling trace moisture is essential in pharmaceutical manufacturing, transformer oil testing, food processing, and chemical synthesis. Moisture in active pharmaceutical ingredients (APIs) and finished tablets leads to chemical degradation, reduced shelf life, and failed stability batches. In dielectric oils, water triggers catastrophic electrical breakdown. Aquastar® CombiTitrant 5 eliminates measurement uncertainties by offering exceptional titer stability and minimal drift over time, ensuring audit-proof compliance with international pharmacopeial protocols (USP <921>, Ph. Eur. 2.5.12).
Unlike traditional Karl Fischer reagents that contain toxic, foul-smelling pyridine, Aquastar® CombiTitrant 5 utilizes non-hazardous imidazole derivatives. This modern formulation provides a safer working environment for laboratory chemists while accelerating the titration reaction rate. It integrates seamlessly with all automated volumetric Karl Fischer titrators (such as Metrohm, Mettler Toledo, Hanna, and SI Analytics) when paired with standard titration solvents like Aquastar® CombiMethanol or CombiSolvent. Victor Scientific Co. supplies original, certified Aquastar® reagents with lot-specific certificates of analysis (CoA) and nationwide delivery across Bangladesh.
✹ Key Features
Pyridine-Free Eco-Friendly Formulation
Replaces toxic pyridine with safer imidazole bases, reducing laboratory exposure risks, unpleasant odors, and hazardous waste disposal burdens.
High-Precision Titer Value (~5 mg H2O/mL)
Optimized for analyzing medium to high moisture concentrations (0.1% to 100% water content) with exceptional analytical repeatability.
Rapid Reaction Kinetics & Sharp Endpoints
Accelerates water-iodine stoichiometry to achieve rapid sample dissolution, reduced drift, and immediate endpoint recognition.
Exceptional Titer Stability
Formulated with high-purity components to ensure stable titer values over extended storage periods, reducing the frequency of daily standardization.
Universal Automated Titrator Compatibility
Directly compatible with automated Karl Fischer titrator instruments from Metrohm, Mettler Toledo, Schott, Hanna Instruments, and Hiranuma.
Traceable Quality & Regulatory Compliance
Manufactured under strict ISO 9001 guidelines and fully certified for testing under USP, EP, BP, and ASTM standards.
✹ Applications
- Pharmaceutical formulation, raw materials, active pharmaceutical ingredients (APIs), and excipient testing
- Dielectric insulating oils, turbine lubricants, and petroleum hydrocarbon moisture analysis (ASTM D1744)
- Food, confectionery, dairy products, edible oils, and freeze-dried food quality control
- Industrial chemical manufacturing, solvent purity verification, and polymer moisture assays
- University analytical chemistry research, chromatography solvent validation, and contract QC testing
- Fertilizer, pesticide, and agrochemical moisture limit determination
✹ Why Choose Aquastar® CombiTitrant 5?
- World-class Merck / Supelco German quality standards guarantee verified batch-to-batch consistency.
- One-component design simplifies laboratory inventory by using a single titrating solution.
- Reduces reagent consumption through high reaction velocity and stable, reproducible endpoints.
- Supplied in tamper-evident, amber glass bottles designed for direct screw-in connection to titrator buret assemblies.
- Guaranteed authentic procurement and technical documentation supported by Victor Scientific Co.
✹ Benefits
- Safeguards drug stability and extends commercial shelf life through accurate moisture quantification.
- Lowers operational downtime with faster sample runs and reduced equilibration wait times.
- Improves laboratory health and safety with an odor-free, non-toxic chemical formulation.
- Streamlines FDA, DGDA, and ISO audits with traceable, lot-certified standard documentation.
✹ About Victor Scientific Co.
Victor Scientific Co. provides quality laboratory equipment, measuring instruments and scientific tools in Bangladesh. We supply reliable products for educational institutions, industries, laboratories and professional users.